Lactate dehydrogenase (LDH), a key enzyme in the glycolytic pathway and a cytoplasmic enzyme found in most organs, has been linked to inflammation response and cell damage. Moreover, acute respiratory distress syndrome (ARDS) is the most frequent cause of admission to intensive care unit in COVID-19 patients ( 1). The most common clinical feature of SARS-CoV-2 infection is fever ( 2). It is now known that Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new type of coronavirus causing COVID-19 infection ( 1). Accepted for publication Aug 03, 2020.Īs of March 9, 2020, more than 100,000 cases of coronavirus disease-2019 (COVID-19) were reported in more than 100 countries with thousands deaths globally. Department of Emergency, The Second Xiangya Hospital, Emergency Medicine and Difficult Disease Institute, Central South University, No.